Here are a few important ones (to me anyway).
- When is Guild Wars 2 going to be released?
- So what is the level cap?
- Am I going to have to endlessly grind to reach the level cap?
- Will there be a healing class?
- How many professions are there going to be?
- Will there still be secondary professions?
- Will professions have racial restrictions?
- Can I change my profession?
- No? But what happens if my race ends up sucking at playing a particular profession?
- Is there going to be any player housing?
- Will there be a pre-searing like area, like in Guild Wars Prophecies?
- What are the races I can play in Guild Wars 2?
- Will there be any other races?
I think that's all the ones I was interested in at the moment. "When it's done" sounds like Blizzard, though.